Is This Thing On? is inspired by a true story, specifically the real-life experiences of British comedian John Bishop, who began stand-up comedy while going through a difficult divorce, finding a unique way to process his life changes on stage. Arnett’s character, Mark, mirrors Bishop’s journey of unexpected self-discovery through comedy during a personal crisis, making it a semi-autobiographical tale rooted in real events.
As their marriage unravels, Alex faces middle age and divorce, seeking new purpose in the New York comedy scene. Meanwhile, his wife Tess confronts sacrifices made for their family, forcing them to navigate co-parenting and identities.